Efficacy Of Hyaluronic Acid And Corticosteroid Intra-Articular Injection In Knee Joint With Primary Osteoarthritis

  • Zaid W. AL-Shahwanii
Keywords: osteoarthritis,, hyaluronic acid,, high molecular weight,, intra-articular injection,, viscosupplementation


Background: Osteoarthritis OA is the most common joint disorder in the world. Injection of high molecular weight hyaluronic acid intra-articular with steroid is a one of the used therapeutic option for patients with (OA)knee.

Objectives: Objective of this study was the evaluation the efficacy, safety, pluse duration of action of viscosupplementation of the  HMWHA( high molecular weight hyluranic acid ).

Type of the study: Cross-sectional study.

Methods: From 81 patients with sever knee pain due to OA (grades 3–4) were recruited from Al-Yarmouk teaching hospital  & a private clinic during the period from January 2014 till July 2016. The patients were  (24 males - 57 females) with mean age 57.14 years( range from 45y -64 y). Visual Analog Scale (VAS) questionnaire for pain, morning stiffness calculated by minuets and physical function were used to assess treatment efficacy after intra-articular HMWHA injection.

Results: The study included 81 patients who gave the examination data and complete the vital baseline and follow-up data necessary  to check for the safety and efficacy .Major improvement was seen after 6 months  from injection, as pain, stiffness and physical activity data  decreased to 20.32, 1.42 and 4.44 respectively. Such achievement continue for  9 months after injection, as the pain marks was 28.3, the stiffness marks was 3.15,while the physical activity marks  was 5.

Conclusions:  injection of HMWHA with steroid intr articular is effective, safe for the period of  9 months for those patients who complain from  moderate and severe OA  knee joint.