The Correlation of Serum Periostin Level with Disease Severity in Patients with Covid -19

Authors

DOI:

https://doi.org/10.47723/pvshyd77

Keywords:

SARS-Cov-2, COVID-19, Periostin, Lung fibrosis, Biomarkers

Abstract

Background: Coronavirus disease 2019 (COVID-19) is an emerging zoonotic disease caused by the new respiratory virus SARS-CoV2. It has a tropism in the lung tissues where excess target receptors exist. Periostin plays a role in subepithelial fibrosis associated with bronchial asthma. Since the Coronavirus's target is the human respiratory system, Periostin has been recently described as a valuable new biomarker in the diagnosis and evaluation of disease in patients with COVID-19 lung involvement.

Objectives: To assess the level of Periostin in the serum of COVID-19 patients and to correlate its role in disease severity and prognosis.

Subjects and Methods: Periostin serum levels were measured for 63 patients attending three main COVID-19 Control Centers in Baghdad, compared to 25 healthy subjects, using an enzyme-linked immunosorbent assay (ELISA) from January 2021 to April 2022.

Results: Serum levels of Periostin among studied groups with (mild - moderate, severe - critical, post-COVID, and controls) were (17.3, 664, 597, and 48) ng/dl respectively. The serum concentration of Periostin was highly significant in (severe- critical and post-COVID) than in other groups.

Conclusions: The elevated level of serum Periostin in COVID-19 patients correlated with disease severity and post-COVID lung complications. The high Periostin level is consistent with high inflammatory markers, which might be used as an indicator of COVID-19 severity and predict a bad prognosis.

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Published

2024-08-01

How to Cite

1.
Ali MH, Abdullah SF. The Correlation of Serum Periostin Level with Disease Severity in Patients with Covid -19. Al-Kindy Col. Med. J [Internet]. 2024 Aug. 1 [cited 2024 Dec. 4];20(2):101-5. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1329

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