mmunohistochemical Identification And Quantification Of Brown Adipocytes In Human Adipose Tissue.

Authors

  • Insaf Jasim Mahmoud
  • Insaf Jasim Mahmoud
  • bdul Hadi Liebi
  • Faris Abdul Kareem Khazaal

Keywords:

uman brown adipocytes, mmunohistochemistry, UCP

Abstract

Background: Obesity is a worldwide challenge and is closely
connected to many metabolic diseases. Two types of
adipose tissue, white adipose tissue (WAT) and brown
adipose tissue (BAT) have been identified. White fat cells
store chemical energy, brown adipocytes defend against
hypothermia, obesity and diabetes.
Objective: To localize and quantify brown adipocytes in
human subcutaneous (S) and visceral (V) adipose tissue by
histology and immunohistochemistry.
Type of the study: A cross –sectional study.
Methods: Adipose tissue was obtained from histopathology
specimens taken from ten patients, of different age, sex and
body mass index (BMI), undergoing surgery for different
pathologies. Immunohistochemistry for detection of UCP
(Uncoupling Protein) in S and V adipose tissue depots was
performed, and percentage of the positive pixels for UCP
color intensity was measured and statistical analysis
performed.data was expressed as mean ± standard
deviation (SD) and analyzed using student t-test to compare
values

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Published

2016-06-30

How to Cite

1.
Mahmoud IJ, Mahmoud IJ, Liebi bdul H, Khazaal FAK. mmunohistochemical Identification And Quantification Of Brown Adipocytes In Human Adipose Tissue. Al-Kindy Col. Med. J [Internet]. 2016 Jun. 30 [cited 2024 Nov. 5];12(2):84-8. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/320

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