VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection

Authors

  • Asmaa B Al-Obaidi Al-Nahrain College of Medicine/Baghdad/Iraq
  • Manal Adnan Habib Baghdad College of Medicine/Baghdad/Iraq
  • Shatha Al-Zuhairy Al-Nahrain College of Medicine/Baghdad/Iraq

Keywords:

human cytomegalovirus,, VCAM-1,, Abortion

Abstract

Background: To elucidate the possible role of human cytomegalovirus in pregnancy loss through induction of certain pro-inflammatory adhesion molecules.
Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein and VCAM-1 molecule.
Results: Nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a
significantly higher expression of VCAM-1 in HCMV positive cases as compared with HCMV negative and the control groups (p = 0.05, 0.001 respectively).
Conclusion: HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the surface expression of pro-inflammatory adhesion molecules like VCAM-1.

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Published

2012-06-30

How to Cite

1.
Al-Obaidi AB, Habib MA, Al-Zuhairy S. VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection. Al-Kindy Col. Med. J [Internet]. 2012 Jun. 30 [cited 2024 Nov. 5];8(1):14-7. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/603

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