Efficiency and Safety of Desferioxamine Chelation Therapy in Paediatric Patients with Transfusion-Dependent Anaemia: Experience of two Centres from Sudan

Authors

  • Atif Ahmed Saad Faculty of Medicine, Omdurman Islamic University, Sudan
  • Samah Ahmed Masaod Faculty of Medicine, Omdurman Islamic University, Sudan
  • Osman Bashir Elhassan Faculty of Medicine, Omdurman Islamic University, Sudan
  • Azza Ahmed Zulfu Department of pathology, faculty of Medicine, Omdurman Islamic University, Sudan

DOI:

https://doi.org/10.47723/kcmj.v18i2.625

Keywords:

Transfusion dependent anemia, Iron chelation therapy, thalassemia, sickle cell anemia, Serum ferritin, desferoxamine

Abstract

Background: Repeated blood transfusion   is   the main   therapeutic option for transfusion-dependent anaemias with consequent iron overload and organ damage .Therefore iron chelating agents are important protective measures for these patients. The aim of this study was  to investigate  the efficiency and safety of Desferroxamine  in paediatrics population subjected  to iron overload as a consequence  of repeated transfusion in a group of  Sudanese children  

Subjects & Methods: This was a descriptive cross-sectional hospital based study.  Conducted in two main paediatric reference hospitals   in, Sudan. Within   the period between November 2017   and   April 2018 (6 months duration).  The   two centres were JaafarI bn- Oaf hospital and Albulk hospital.  The study population included all patients of transfusion dependent anaemia who received desferrioxamine within the study period. Hundred   patients were enrolled in the study. The study variables  were  demographic data, number of blood transfusions , serum ferritin  pre and post  blood transfusion and treatment of desferrioxamin

Results: Sixty percent (60%)  of the studied cases  were males and 40% were females ,46%  were thalassemic, 46%  were sicklers,  5% aplastic anemia and 3% with red cell aplasia .The mean  serum ferritin level before starting desferoxamine  was 2.14 and after dessferoxamine  was  2.48,   P –value  was  highly significant.  The most common side effect encountered   was skin rash (36%)

Conclusion: This study revealed some features of   safety and efficiency of desferoxamine therapy   in Sudanese paediatrics population affected by transfusion-dependent anemia. More studies are needed to   describe this important health problem

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Published

2022-08-31

How to Cite

Saad, A. A., Masaod, S. A., Elhassan, O. B., & Zulfu, A. A. (2022). Efficiency and Safety of Desferioxamine Chelation Therapy in Paediatric Patients with Transfusion-Dependent Anaemia: Experience of two Centres from Sudan . AL-Kindy College Medical Journal, 18(2), 132–135. https://doi.org/10.47723/kcmj.v18i2.625