Association of some Viral infections and asthma: serological evidence

Abstract

Background: It is well known that mycotic antigens have an important
role in atopy and the induction of asthma. Now one of the important
subjects is the relation between respiratory bacterial and viral
infections in the inflammatory reactions accompanied with bronchial
asthma viruses Bacteria or their metabolites act as trigger for asthma
or increase it's intensity .
Objectives: To show the relation between asthma and some viral
infections serologically.
Methods: Direct ELISA test was employed to detect lgG specific for
Respiratory Syncytial virus (Rsv) parainfluenza virus type (p13) and
influenza virus in sera of (100) asthmatic patients of two age groups.
(10-17) and(18-50) years old. Serum samples from(32) intact control
individuals of the same age groups were also investigated.
Results: significant mean values of lgG specific for parainfluenza type-3
and Respiratory Syncytial viruse were found incontrast to normal
control individuals. Non significant values of lgG specific for influenza
virus were detected in asthmatics in contrast to control normal
individuals.
Conclusion: Respiratory Syncytial virus appears to be a prominent cause
of concomitant infections in asthmatic children and some adults as
well as parainfluenza virus type-3 within age group ( 10-17) years old
asthmatics so RSV and p1-3 viruses may be contributers to asthma
severity in asthmatic patients.