Association between HLA and Guillain Barre' syndrome

Authors

  • Hyam Raouf l-Kindy College of medicine-Baghdad University

Keywords:

Guillain Barre, HLA, PCR.

Abstract

Background: Genetic factors play an important role in susceptibility to Guillain Barre' syndrome. Human leukocyte antigen (HLA) as part of immune system has a role in the disease process.Aim of the study: to assess the relationship between HLA-A alleles with Guillain Barre' syndrome (GBS) compared with a healthy control group using PCR-SSOP method.Type of the study: Cross-sectional study.Patients and methods:Patient's group consisted of 30 Iraqi Arab Muslims patients with Guillain Barre' syndrome that consulted the Neurological department in Neurosciences Hospital between January-2013 to January- 2014 were genotyped for HLA-A alleles. A control group consisted of 30 healthy volunteers among the staff of AL-Kindi College of Medicine that did not have any neurological disorders.Results: Present study found a decreased frequency of HLA-A:0101 allele (p=0.001) in GBS patients compared to healthy controls.Conclusions: current results suggest that GBS is negatively associated with HLA-A:0101 allele.

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Published

2016-06-30

How to Cite

1.
Raouf H. Association between HLA and Guillain Barre’ syndrome. Al-Kindy Col. Med. J [Internet]. 2016 Jun. 30 [cited 2024 Nov. 5];12(1):109-11. Available from: https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/353

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