A Role of Therapy that Targets Immune Checkpoint Proteins for the Treatment of Melanoma Brain Metastasis, Liver, Breast, Pancreatic Cancer and Pancreatic Adenocarcinoma

Authors

  • Smaa Elsayed Mohammed 1 Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Basma Aml Youssef Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Doaa Alaa Ghonai Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Eman Fares Ahmed Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Esraa Gharieb Mohammed Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Mai Ashraf Abdo Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Mai Essam Mohammed Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Rana Gharieb Hassan Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Reem Mohammed Mohammed Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Rofida Ahmed Abd Al-Azeem Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Sarah Adel Swelem Department of pharmacology and toxicology, Faculty of pharmacy, Suez Canal University, Egypt
  • Sarah Ouda Salman Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Sarah Mohammed Al-aiyq Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Toka Taha Taha Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt
  • Zainab Khalid Moawad Department of pharmacology and toxicology, Faculty of pharmacy Suez Canal University, Egypt

DOI:

https://doi.org/10.47723/kcmj.v18i3.798

Keywords:

Immune checkpoints, Immune therapt, Cancer

Abstract

Checkpoint inhibitors are a type of immune therapy used to treat different types of cancers. These drugs block different checkpoint proteins, for example, CTLA-4, PD-1, and PD-L1 inhibitors.

They block proteins that stop the immune system from attacking the cancer cells.  Checkpoints are also described as a type of monoclonal antibody that antagonizes binding between B7 to CTLA-4 and PD-L1 to PD-1.

 Immune checkpoint inhibitors are used to treat BARCA mutated triple-negative breast cancer (TNBCS) in patients who do not respond to chemotherapy, and also in the treatment of highly mutated and solid tumors such as brain tumors, liver, and pancreatic cancers.

Immune checkpoint inhibitors exhibit an effect on solid tumors by suppressing CTLA-4, PD-1, and PDL-1. Anti-PD-1 is less toxic than anti-CTLA-4.

For melanoma Brain metastasis immune checkpoint therapy is more effective and Combination therapy has great efficacy and less toxicity which improves overall survival rather than individual therapy

liver cancer as hepatocellular carcinoma and cholangiocarcinoma used treatment with Genetics based therapy while using alternative immune checkpoint ligands, co-inhibitory (eg. LAG-3) or decreased t-cell infiltration causing therapy failure.

Clinical studies for pancreatic cancer have not been completed yet and treating PDA needs more research as immune checkpoint inhibitors is a new treatment against  PDA. A new potent class of nivolumab, pembrolizumab, and ipilimumab have been FDA approved.

For mutated tumors, Combination therapy between checkpoint inhibitors and chemotherapy has great efficacy and improves the city of life and overall survival, rather than individual therapy when using radiation or chemotherapy alone.

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Published

2022-12-31

How to Cite

Mohammed, S. E., Youssef, B. A., Ghonai, D. A., Ahmed, E. F., Mohammed, E. G., Abdo, M. A., Mohammed, M. E., Hassan, R. G., Mohammed, R. . M., Abd Al-Azeem, R. A., Swelem, S. A., Salman, S. O., Al-aiyq, S. M., Taha, T. T., & Moawad, Z. K. (2022). A Role of Therapy that Targets Immune Checkpoint Proteins for the Treatment of Melanoma Brain Metastasis, Liver, Breast, Pancreatic Cancer and Pancreatic Adenocarcinoma. AL-Kindy College Medical Journal, 18(3), 173–180. https://doi.org/10.47723/kcmj.v18i3.798